
We're doing SERIOUS research
which requires complete and utter focus.
The Big Bang Theory Season 3, Episode 4

It's usually not SERIOUS,
but it can produce a cough like that.
Breaking Bad Season 2, Episode 9

You are not SERIOUS.
The Big Bang Theory Season 12, Episode 17

Really? You're SERIOUS?
The Big Bang Theory Season 6, Episode 3

Are you SERIOUS? For what?
The Big Bang Theory Season 7, Episode 12