Noun
1. misfortune
2. ill luck
3. bad luck
4. trouble
5. difficulty
6. hardship
7. distress
8. disaster
9. suffering
10. affliction
11. sorrow
12. misery
13. tribulation
14. woe
15. pain
16. trauma
17. mishap
18. misadventure
19. accident
20. upset
21. reverse
22. setback
23. crisis
24. catastrophe
25. tragedy
26. calamity
27. trial
28. cross
29. burden
30. blow
31. hard times
32. trials and tribulations
33. ill wind